The Osta Value Proposition
A process has been design and patented to produce a high surface area originating from cow bone (Figure B4). The specific surface area is a measure of the space for blood vessels and bone ingrowth. Weibrich et al, compared the specific surface area of 12 different bone substitutes (Figure B5). Osta Maxigro™ and Osta Regigro ™ appear to be the highest surface area Osteoconductive Xenografts based on this comparison. (Compare Fig B4 & B5)
Why does this happen?
A possible explanation is that the quantity of proteins adsorbed on particles positively correlates with their specific surface area. Nanosized particles adsorbed significantly greater amounts of proteins, and induced enhancement of subsequent cell adhe¬sion and proliferation during the bone regeneration process.
The basis for Osteobalstic–HA adhesion and the effect of grain boundary volume on Osteoblastic behaviour are not completely understood, but may be linked in part to protein interactions at the surface. Cai et al found that a decrease in grain size promoted an increase in vitronectin and collagen concentration and a decrease in albumin, laminin, and fibronectin concentrations (Cai,Y et al, J.Mater Chem, 2007,17, 3780-3787)
What is the Advantage of High Surface Area?
Osta Maxigro™ and Osta Regigro ™ appear to be the highest surface area Osteoconductive Xenografts based on this comparison. (Compare Figures). These materials made up of Nanosized particles are expected to adsorb significantly greater amounts of proteins, and induce enhancement of subsequent cell adhesion and proliferation during the bone regeneration process.
What is the clinical advantage?
Since the quantity of proteins adsorbed on particles positively correlates with their specific surface area, there is increased vascularization with higher surface area and this is the basis Osteoblastic–HA adhesion.
Cai et al found that a decrease in grain size promoted an increase in vitronectin and collagen concentration and a decrease in albumin, laminin, and fibronectin concentrations (Cai,Y et al, J.Mater Chem, 2007,17, 3780-3787). It is hypothesized that this enhances the bone regeneration repair process.
